The Methylenetetrahydrofolate Reductase C677T Polymorphism in Patients with Esophageal Cancer
نویسندگان
چکیده
منابع مشابه
Methylenetetrahydrofolate Reductase C677T Influences Risk of Esophageal Cancer in Chinese
Esophageal cancer (EC) is a global health problem, and an estimated 482,300 new esophageal cancer cases and 406,800 deaths occurred in 2008 worldwide (Jemal et al., 2011). Its incidence rates vary internationally, and the highest rates found in Southern and Eastern Africa and Eastern Asia were nearly 16-fold, compared with lowest rates observed in Western and Middle Africa and Central America i...
متن کاملImpact of Methylenetetrahydrofolate Reductase C677T Polymorphism on the Risk of Gastric Cancer and Its Interaction with Helicobacter pylori Infection
Background: Attempts for early detection of gastric cancer have recently focused on host's genetic susceptibility factors and gene-environment interactions. We have, herein, studied the association of MTHFR C677T single nucleotide polymorphism (SNP) and its interaction with Helicobacter pylori infection, smoking, age and gender on the risk of gastric cancer among an Iranian population. Methods:...
متن کاملEvaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...
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Several epidemiological studies have examined the relationship of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with hyperuricemia. However, the results were controversial. We therefore conducted a large cross-sectional study (2,219 subjects) and an updated meta-analysis by combining previous studies (9,502 subjects) to provide more empirical evidence for the association. A...
متن کاملRisk of colorectal cancer associated with the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in the Kashmiri population.
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer. The 677 C→T polymorphism has been widely investigated in different cancers and has been implicated as a risk fa...
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ژورنال
عنوان ژورنال: Journal of Carcinogenesis & Mutagenesis
سال: 2019
ISSN: 2157-2518
DOI: 10.4172/2157-2518.1000333